ABSTRACTThere is an ongoing debate in New Testament scholarship on the correct interpretation of Paul’s pistis Christou formulations: are we justified by our own faith/trust in Christ, or by participating in Christ’s faith and faithfulness towards God? This article contributes to the position of purposeful or sustained ambiguity by reading Paul’s imitation – and faith – language against the background of Hellenistic-Roman thought on and practice of imitation. In particular, the mimetic chain between teachers and students training for a philosophical (...) disposition, and the philosophical topos of ‘becoming like God’ offer material valuable for comparison. Since pistis, fides and cognates are used in these settings as both a quality to imitate and as attitude towards a model, and since, conversely, imitation is very much involved in Paul’s pistis-vocabulary, it makes sense to read pistis Christou as shorthand for a mimetic movement of faith via Christ towards God. (shrink)

The human immune system can directly lyse invading micro‐organisms and aberrant host cells by generating pores in the cell envelope, called membrane attack complexes (MACs). Recent studies using single‐particle cryoelectron microscopy have revealed that the MAC is an asymmetric, flexible pore and have provided a structural basis on how the MAC ruptures single lipid membranes. Despite these insights, it remains unclear how the MAC ruptures the composite cell envelope of Gram‐negative bacteria. Recent functional studies on Gram‐negative bacteria elucidate that local (...) assembly of MAC pores by surface‐bound C5 convertase enzymes is essential to stably insert these pores into the bacterial outer membrane (OM). These convertase‐generated MAC pores can subsequently efficiently damage the bacterial inner membrane (IM), which is essential for bacterial killing. This review summarizes these recent insights of MAC assembly and discusses how MAC pores kill Gram‐negative bacteria. Furthermore, this review elaborates on how MAC‐dependent OM damage could lead to IM destabilization, which is currently not well understood. A better understanding on how MAC pores kill bacteria could facilitate the future development of novel strategies to treat infections with Gram‐negative bacteria. (shrink)

In recent years, membrane contact sites (MCS), which mediate interactions between virtually all subcellular organelles, have been extensively characterized and shown to be essential for intracellular communication. In this review essay, we focus on an emerging topic: the regulation of MCS. Focusing on the tether proteins themselves, we discuss some of the known mechanisms which can control organelle tethering events and identify apparent common regulatory hubs, such as the VAP interface at the endoplasmic reticulum (ER). We also highlight several currently (...) hypothetical concepts, including the idea of tether oligomerization and redox regulation playing a role in MCS formation. We identify gaps in our current understanding, such as the identity of the majority of kinases/phosphatases involved in tether modification and conclude that a holistic approach—incorporating the formation of multiple MCS, regulated by interconnected regulatory modulators—may be required to fully appreciate the true complexity of these fascinating intracellular communication systems. (shrink)

Neurocognitive enhancement, or cosmetic neurology, offers the prospect of improving the learning, memory and attention skills of healthy individuals well beyond the normal human range. Much has been written about the ethics of such enhancement, but policy-makers in the USA, the UK and Europe have been reluctant to legislate in this rapidly developing field. However, the possibility of discrimination by employers and insurers against individuals who choose not to engage in such enhancement is a serious threat worthy of legislative intervention. (...) While lawmakers should not prevent individuals from freely pursuing neurocognitive enhancement, they should act to ensure that such enhancement is not coerced. This paper offers one model for such legislation, based upon a proposed US law, the Genetic Information Nondiscrimination Act of 2008, to address precisely this particular pitfall of the impending neuroscience revolution. (shrink)

Book reviewed in this article: Just War Tradition and the Restraint of War: A Moral and Historical Inquiry. By James Turner Johnson.

It is the persistence of social suffering in a world in which it could be eliminated that for Adorno is the source of the need for critical reflection, for philosophy. Philosophy continues and gains its cultural place because an as yet unbridgeable abyss separates the social potential for the relief of unnecessary human suffering and its emphatic continuance. Philosophy now is the culturally bound repository for the systematic acknowledgement and articulation of the meaning of the expanse of human suffering within (...) technologically advanced societies that are already committed to liberal ideals of freedom and equality. (shrink)

persuasive argument for the claim that we ought to evaluate mathematics from a mathematical point of view and reject extra-mathematical standards. Maddy considers the objection that her arguments leave it open for an ‘astrological naturalist’ to make an analogous claim: that we ought to reject extra-astrological standards in the evaluation of astrology. In this paper, I attempt to show that Maddy's response to this objection is insufficient, for it ultimately either (1) undermines mathematical naturalism itself, leaving us with only scientific (...) naturalism, or (2) leaves open the possibility of other unpalatable naturalisms. (shrink)

Ethical consumerism is the thesis that we should let our values determine our consumer purchases. We should purchase items that accord with our values and refrain from buying those that do not. The end goal, for ethical consumerism, is to transform the market through consumer demand. The arm of this movement associated with food choice embraces the slogan “Vote with Your Fork!” As in the more general movement, the idea is that we should let our values dictate our choices. In (...) this paper, I offer a critique of the Vote with Your Fork campaign (hereafter VWYF) that focuses on the agency of individuals. For VWYF to be effective, minimally, individuals must act _intentionally_ when making food choices. In the ideal case, individuals adopt and endorse the values implicit in VWYF and exhibit _autonomous agency_ when they purchase and consume food. The problem, though, is that a number of things can go wrong along the way. I argue that very few of us are in the position to exhibit autonomous agency with respect to our food choices. Because of this, VWYF could very well undermine its own goals. (shrink)

Thirty-three physicians, bioethicists, and medical economists from ten different countries met at Lawrence University, Appleton, Wisconsin, to create The Appleton Consensus: International Guidelines for Decisions to Forego Medical Treatment. The guidelines deal with four specific decision-making circumstances: 1. Five guidelines were created for decisions involving competent patients or patients who have executed an advance directive before becoming incompetent, and those guidelines fell into three categories. 2. Thirteen guidelines were created for decisions involving patients who were once competent, but are not (...) now competent, who have not executed an advance directive. 3. Seven guidelines were created for decisions involving patients who are not now and never have been competent, for whom 'no substituted judgement' can be rendered. 4. Eleven guidelines were created for decisions involving the scarcity of medical resources, which exists in all communities. Five concepts were identified as being critical in the establishment of priorities, given the reality of scarce health resources (1). The term 'physician' is used in the American sense, synonymous with 'medical practitioner'. (shrink)

In this article I elucidate a conception of small worlds, or ‘ontological’ contexts, within the curriculum that stand out and beyond the horizon of technological‐scientific reality, which might be linked with forgotten, marginal ways of being and thinking. As I attempt to demonstrate, it is possible that such ontological worlds apart from technology's ‘Enframing’ effect might inspire the type of meditative thinking in our classrooms that is consistent with Heidegger's notion of authentic worldly dwelling as it appears in the later (...) writings of the 1930s, or the ‘turn’. (shrink)

John Locke claimed that: ‘We never finding, nor conceiving it possible, that two things of the same kind should exist in the same place at the same time, we rightly conclude that, whatever exists anywhere at any time excludes all of the same kind, and is there itself alone’. He argued that, otherwise, ‘The notions and names of identity and diversity would be in vain, and there could be no such distinctions of substances or anything else one from another’. More (...) recently Professor D. Wiggins has made a similar claim for similar reasons. I shall maintain that, even if we accept the general outline of the essentialist account of identity given by Wiggins in his book, the claim that two things of the same kind cannot be in the same place at the same time should be rejected, until better reasons are forthcoming. (shrink)

This paper presents a new foundation of equilibrium thermodynamics based on certain ideas of T. Ehrenfest. The main result is the proof for the existence of entropy as a consequence of the conservation of energy for conservative thermal systems.

Tenseless theories of time entail that the only temporal properties exemplified by events are earlier than, simultaneous with, and later than. Such an account seems to conflict with our common experience of time, which suggests that the present moment is ontologically unique and that time flows. Some have argued that only a tensed account of time, one in which past, present and future are objective properties, can do justice to our experience. Any theory that claims that the world is different (...) from how we experience it must nonetheless be consistent with the having of that experience. Accordingly, in this essay I defend the tenseless theory by arguing that it can indeed account for certain key features of our experience of time without recourse to tensed properties. (shrink)

In most areas of our lives, legal protections are in place to ensure that we have autonomous control over what happens in and to our bodies. However, there are fewer protections in place for autonomous choice when it comes to the food we purchase and consume. In fact, the current trend in US legislation is pushing us away from autonomous food choice. In this paper, I discuss two examples of this trend: corporate resistance to GM labeling laws and farm protection (...) laws. These examples are quite different from a legislative point of view. In one case, laws that would promote autonomous choice are actively resisted, whereas in the other case, laws that undermine autonomy are enacted. The common core of the two examples is the effect: in both cases, we are unable to determine whether the food we purchase and consume is consistent with our values. In both cases, then, autonomous choice about the food we purchase and put into our bodies is undermined. (shrink)

Categorical proof theory is an approach to understanding the structure of proofs. We illustrate the idea first by analyzing G0̈del's Dialectica interpretation and the Diller-Nahm variant in categorical terms. Then we consider the problematic question of the structure of classical proofs. We show how double negation translations apply in the case of the Dialectica interpretations. Finally we formulate a proposal as to how to give a more faithful analysis of proofs in the sequent calculus.

Emotion inheres simultaneously in individuals and in the social structures and relationships in which individuals are embedded. Beginning with a critical examination of T.H. Marshall's account of class resentment, this paper considers the emotional patterns of resentment in class inequality, in trade cycle changes in costs and opportunities for income, and in class cultures. Arising from social relationships, emotion is the basis of action that subsequently affects the structure of social relationships. Thus emotion connects phases of social structure separated by (...) time. (shrink)

Most discussions of near-death experiences (NDEs) in both the academic and popular literature contend that they establish ('prove') supernaturalism (about NDEs): they show that the mind is not the brain (and can continue after the brain stops functioning), and they bring us into contact with non-physical realms. I believe that the evidence provided by NDEs for supernaturalism is not persuasive, but I offer an alternative, naturalistic interpretation of these phenomena. On this interpretation, NDEs are 'real' in both senses of the (...) term: they really occur (people really have them, with the experiential content ascribed to them), and they are accurate. On this interpretation, NDEs are fundamentally about a journey from the known to the unknown, guided by a trusted mentor. Thus, NDEs accurately depict the possibilities for dying. Negative NDEs indicate the possibility of dying in cold, sterile, lonely circumstances, whereas positive NDEs point to the possibility of 'dying well', surrounded by loved ones. This is an interpretation that avoids the problems for supernaturalism of the gap between evidence and conclusion, and the commitment to causal interaction between physical and non-physical realms. (shrink)

We offer obeisances to Lord Śiva, guru of knowledge, lord of the dance, who purifies by the very utterance of his name, who transcends all dualities. May he grant us permission to argue with his devotees. May he also give us his blessings to convince them.Properly speaking, comparative philosophy does not lead toward the creation of a synthesis of philosophical traditions. What is being created is not a new theory but a different sort of philosopher. The goal of comparative philosophy (...) is learning a new language, a new way of talking. The comparative philosopher does not so much inhabit both of the standpoints represented by the traditions from which he draws as he comes to inhabit an.. (shrink)

In an important recent article T. C. W. Stinton reaffirmed the case that in Aristotle's Poetics, ch. 13, has a wide range of application. I do not wish to dispute the general conclusion of what seems to me a masterly analysis of the question but simply to discuss two areas where Stinton's argument may be thought defective–the interpretation of the examples given by Aristotle in Poetics 13, 5 3all and 53a2O–1 and the problem of the contradiction between 13, 53a13–15 and (...) 14, 54a4–9. (shrink)

Professor Leonard proposes that imperative and interrogative sentences be classified, together with declarative ones, as true and false. The interesting analysis he gives in connection with this proposal points out that these three types of utterance have something in common and has the merit of evincing the identity of this common element. Also it may seem to offer attractive possibilities of integrating various types of discourse in its promise of partial assimilation of interrogatives and imperatives to the model of truth-valuable (...) language. Even so, Leonard's account is not altogether satisfactory. I shall not discuss his treatment of imperatives but shall argue that his conception of interrogatives has unacceptable consequences. (shrink)

Whether the law should permit individuals to opt out of accepted death standards is a question that must be faced and clarifiedWhile media coverage of the Terri Schiavo case in Florida has recently refocused public attention on end of life decision making, another end of life tragedy in Utah has raised equally challenging—and possibly more fundamental—questions about the roles of physicians and families in matters of death. The patient at the centre of this case was Jesse Koochin, a six year (...) old boy suffering from “inoperable and incurable” brain cancer. He had been undergoing care at Primary Children’s Medical Center in Salt Lake City since September 15, 2004 when “his tumor pushed his brain stem down through the skull”.1 Subsequently, two physicians independently determined that the child was “brain dead” and informed his parents that they would order life support removed within twenty four hours. Steve and Gayle Koochin overtly rejected the hospital’s definition of death. The couple, relying on traditional notions of cardiopulmonary death, obtained a restraining order to keep Jesse on a ventilator and ultimately removed the brain dead child from the hospital. The ongoing case raises the complex question of whether patients’ families should be permitted to opt out of widely accepted definitions of death in favour of their own standards.The definition of death has evolved rapidly in the United States over the past thirty five years. Until the middle of the twentieth century, the medical community, the legal system, and an overwhelming majority of the public understood death to …. (shrink)

The latter part of the 20th century is known for a surge in the so-called ‘genitive theologies’. Usually, a genitive theology has an ulterior motive, aiming at the transformation of a society or the promotion of sound politics and economy. In recent years, this trend culminated in public theology. The issue of religion with an ulterior motive was raised by Van de Beek in a seminal article focusing on theology without gaining anything from it as an answer to the surging (...) genitive theologies of the latter part of the 20th century and the public theologies of today. Taking into account Van de Beek’s critique against ‘religion with an ulterior motive’, this article explores the concept of the church as a moral agent in dialogue with Van de Beek. The central theoretical argument of this investigation is that Van de Beek’s ecclesiology is valuable when defining the role of the church as a moral agent. However, the perspective of the Kingdom of God concerning the church can enrich one’s views and can add value to his valid critique on public theology. (shrink)

Ouvrage à deux voix qui propose deux manières d'envisager le dialogue ou la rencontre de la phénoménologie et de la science, de lire les textes phénoménologiques et enfin d'envisager un avenir de la recherche en phénoménologie.